For our latest publications, click for Pubmed or Google Scholar.
2026
Caitlin Hudecek and Michael D. Burkart., Flowzonolysis: Continuous Oxidative Ozonolysis of Algae‐Derived Palmitoleic Acid for the Synthesis of Azelaic Acid. Chemistry-Europe 2026, 6(7).
Satyan Khanal, Alessandro Fracassi, Alexander Harjung, Michael D. Burkart & Neal K. Devaraj., Breaking the membrane heredity paradox through de novo protocell formation. Nature Communications 2026, 17.
Aaron Bruckbauer, Kathryn M. J. Wnuk-Fink, Thomas Frisch, Aanchal Jaisingh, and Michael D. Burkart., Toward Fully Renewable Rigid Polyurethane Foams with Aliphatic Diisocyanates. Biomacromolecules 2026, 27(6).
2025
Kathryn M.J. Wnuk-Fink, Aanchal Jaisingh, Caitlin Hudecek, Matthew W. Halloran, Robert J. Chambers, William C. Chan, Aaron Bruckbauer, Emma Luppi, Nithish A. Chakravarthy, Robert S. Pomeroy, Shengqiang Cai, and Michael D. Burkart., Advancing Renewable Materials via Microalgae-Derived Thermoplastic Polyester Polyurethanes. ACS Sustainable Chemistry & Engineering 2025, 13 (50), 21622-21632.
Matthew W. Halloran, Aaron H. Forman, Aanchal Jaisingh, Amal Patel, Bhausaheb S. Rajput, Thien An Phung Hai, and Michael D. Burkart., A Scalable Route to Renewable 1,7-Heptamethylene Diisocyanate in Flow. Organic Process Research & Development 2025, 29 (12), 3173-3178.
Aaron Bruckbauer, Samuel S. Hays, Zhecun Guan, Thomas Frisch, Katherine O’Shea, Stephen P. Mayfield, Jinhye Bae, Jonathan K. Pokorski, and Michael D. Burkart., Enhancing the Performance of Thermoplastic Polyurethanes Using Renewable Aromatic Moieties. ACS Applied Polymer Materials 2025, 7 (19), 13226-13235.
Yixing Suo, Ziran Jiang, Graham W. Heberlig, Elsabella Y. Wang, Banumathi Sankaran, James J. La Clair, and Michael D. Burkart., Role of Human Mitochondrial Ketosynthase in Long-Chain Fatty Acid Biosynthesis. Journal of the American Chemical Society 2025, 147 (36), 33248-33255.
Jiang Z, Heberlig GW, Chen JA, Huynh J, La Clair JJ, Burkart MD., Visualizing acyl carrier protein interactions within a crosslinked type I polyketide synthase.. Nature Communications 2025, 16(1):7798.
Rebecca N. Re, Caitlin Hudecek, Aanchal Jaisingh, Matthew W. Halloran, Aaron Bruckbauer, Kathryn M. J. Wnuk-Fink, Arushi Dev, Nikita Harwich, Maeva Subileau, James J. La Clair, and Michael D. Burkart., Co-Catalyst Enabled Biotransformation of Polyunsaturated Fatty Acids for Biobased Monomers. Organic Process Research & Development 2025, 29 (9), 2265-2274.
Jeffrey A. Chen, Yixing Suo, Stephen P. Mayfield, and Michael D. Burkart., Structural Characterization of an Endogenous Algal Acyl-ACP Thioesterase. Biochemistry 2025, 64 (16), 3508-3514.
Abhishek Gupta, Aaron Oliver, João Vitor Dutra Molino, Kathryn MJ Wnuk-Fink, Marissa Tessman, Kalisa Kang, Évellin do Espirito Santo, Yasin Torres-Tiji, Michael D Burkart, Stephen Mayfield., Identification and overexpression of endogenous transcription factors to enhance lipid accumulation in the biotechnologically relevant species Chlamydomonas pacifica. Algal Research 2025
Arthur J. Altunc, Eunkeu Oh, Konrad Meister, Meghna Thakur, Kimihiro Susumu, and Michael D. Burkart., Optimization of the Gold Nanoparticle Colorimetric Assay for Screening and Quantifying Ice Recrystallization Inhibition Activity of Antifreeze Proteins. Langmuir 2025, 41(25), 16435-16447.
Crisandra Jade Diaz, João Vitor Dutra Molino, Barbara Saucedo, Kalisa Kang, Évellin do Espirito Santo, Michael D. Burkart, and Stephen P. Mayfield., Sustainable production of plastic-degrading enzymes in microalgae. bioRxiv 2025, 10.1101/2025.05.14.654053.
Satyam Khanal, Alessandro Fracassi, Alexander Harjung, Michael D. Burkart, and Neal K. Devaraj, De Novo Protocell Membrane Formation Fueled by Primitive Metabolites. bioRxiv 2025, 10.1101/2025.05.10.653202.
Rebecca N. Re, James J. La Clair, Joseph P. Noel, and Michael D. Burkart., Eluciding the Iterative Elongation Mechanism in a Type III Polyketide Synthase. Journal of the American Chemical Society 2025, 147, 16705–16714.
Arthur J. Altunc, Eunkeu Oh, Konrad Meister, Meghna Thakur, Kimihiro Susumu, and Michael D. Burkart., Systematic Development of a Plasmon Ruler Using Dithiolate-Grafted Gold Nanoparticle for High-Throughput Screening of Anti-Icing Activity. ACS Applied Nano Materials 2025.
Aaron Bruckbauer, Gordon B. Scofield, Thomas Frisch, Matthew W. Halloran, Zhecun Guan, Kathryn M.J. Wnuk-Fink, Marco N. Allemann, Katherine O’Shea, Ryan Simkovsky, Jinhye Bae, and Michael D. Burkart., Rethinking Polyurethane Dogma for Fully Renewable and Biodegradable Foams. Chemistry of Materials 2025.
Graham W. Heberlig, James J. La Clair and Michael D. Burkart., Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis. Nature 2024, 636.
E. R. Smith, D. H. Al-Smadi, Y. Dai, M. Khin, J. E. Burdette, B. M. Duggan, J. J. La Clair, A. S. Eustáquio, and M. D. Burkart., Engineering regiospecific methylation of the pladienolides. RSC Chemical Biology 2025, 6, 1126-1134.
2024
Desirae A. Mellor, Yixing Suo, Matthew G. Miyada, Grace A. Medina Perez, and Michael D. Burkart., Manipulation and Structural Activity of AcpM in Mycobacterium tuberculosis. Biochemistry 2024.
Crisandra Jade Diaz, Barbara Saucedo, Ayesha Malik, Michael D. Burkart, and Stephen P. Mayfield., Engineering the Novel Extremophile Alga Chlamydomonas pacifica for High Lipid and High Starch Production as a Path to Developing Commercially Relevant Strains. ACS ES&T Engineering 2024, 5(1):36-49.
Yixing Suo, Aochiu Chen, James J. La Clair, and Michael D. Burkart., Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein. Biochimica et Biophysica Acta (BBA) - Biomembranes 2024.
Loles Hoogerland, Stefan Pieter Hendrik van den Berg, Yixing Suo, Yuta W. Moriuchi, Adja Zoumaro-Djayoon, Esther Geurken, Flora Yang, Frank Bruggeman, Michael D. Burkart, and Gregory Bokinsky., A temperature-sensitive metabolic valve and a transcriptional feedback loop drive rapid homeoviscous adaptation in Escherichia coli. Nature Communications 2024, 15(1):9386.
Marco N. Allemann, Stacey Ma, Terra Sztain, Thomas G. Bartholow, Ian P.G. Marshall, J. Andrew McCammon, Michael Burkart, Eric E. Allen, Douglas H. Bartlett, and Angeliki Marietou., Adaptation to high pressure; insights from the genome of an evolved Escherichia coli strain with increased piezotolerance. bioRxiv 2024, 10.1101/2024.09.24.613341.
Jaisingh, A.; Halloran, M. W.; Rajput, B. S.; Burkart, M. D., Tailoring High Hardness and Rigidity in Biodegradable Thermoplastic Polyurethanes. ACS Appl. Polym. Mater. 2024, 6 (16), 9724-9734.
Jiang, Z.; Chen, J. A.; Mohamed, O. G.; Huynh, J.; Chen, A.; Tripathi, A.; La Clair, J. J.; Burkart, M. D., Cryptic Cerulenin Rearrangement in Ketosynthase Covalent Inhibition. J. Am. Chem. Soc. 2024, 146 (29), 20370-20378.
Miyada, M. G.; Choi, Y.; Stepanauskas, R.; Woyke, T.; La Clair, J. J.; Burkart, M. D., Fluorometric Analysis of Carrier-Protein-Dependent Biosynthesis through a Conformationally Sensitive Solvatochromic Pantetheinamide Probe. ACS Chem. Biol. 2024, 19 (7), 1416-1425.
Kalaj, B. N.; La Clair, J. J.; Shen, Y.; Schwieters, C. D.; Deshmukh, L.; Burkart, M. D., Quantitative Characterization of Chain-Flipping of Acyl Carrier Protein of Escherichia coli Using Chemical Exchange NMR. J. Am. Chem. Soc. 2024, 146 (27), 18650-18660.
Bruckbauer, A.; Scofield, G. B.; Allemann, M. N.; Reindel, J.; Zhao, J.; Howell, A. N.; Frisch, T.; Johnson, L.; Evans, P.; Pomeroy, R. S.; Simkovsky, R.; Bae, J.; Mayfield, S. P.; Burkart, M. D., Renewable and Biodegradable Polyurethane Foams with Aliphatic Diisocyanates. Macromolecules 2024, 57 (6), 2879-2887.
Chen, A.; Re, R. N.; Davis, T. D.; Tran, K.; Moriuchi, Y. W.; Wu, S.; La Clair, J. J.; Louie, G. V.; Bowman, M. E.; Clarke, D. J.; Mackay, C. L.; Campopiano, D. J.; Noel, J. P.; Burkart, M. D., Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes. J. Am. Chem. Soc. 2024, 146 (2), 1388-1395.
2023
Suo, Y.; Chen, A.; La Clair, J. J.; Burkart, M. D., Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein. Biochem. 2023, 62 (24), 3548-3553.
Rajput, B. S.; Forman, A.; Halloran, M. W.; Hai, T. A. P.; Scofield, G. B.; Burkart, M. D., Variation of Aliphatic Diisocyanates in Bio-Based TPUs. Macromolecules 2023, 56 (21), 8813-8822.
Patel, A.; Rajput, B. S.; Hai, T. A. P.; Zhen, D.; Gunawan, N. R.; Tessman, M.; Reindel, J.; Shepherd, J.; Simkovsky, R.; Pomeroy, R. S.; Pourahmady, N.; Mayfield, S. P.; Burkart, M. D., Biodegradable waterborne polyurethane-urea dispersion adhesives with high biocontent. J. Appl. Polym. Sci. 2023, 140 (34), e54307.
Sztain, T.; Corpuz, J. C.; Bartholow, T. G.; Sanlley Hernandez, J. O.; Jiang, Z.; Mellor, D. A.; Heberlig, G. W.; La Clair, J. J.; McCammon, J. A.; Burkart, M. D., Interface Engineering of Carrier-Protein-Dependent Metabolic Pathways. ACS Chem. Biol. 2023, 18 (9), 2014-2022.
Halloran, M. W.; Hudecek, C.; Burkart, M. D., Synthesis of Acid Hydrazides from Carboxylic Acids in Continuous Flow. Org. Process Res. Dev. 2023, 27 (9), 1677-1683.
Džunková, M.; La Clair, J. J.; Tyml, T. et al., Synthase-selected sorting approach identifies a beta-lactone synthase in a nudibranch symbiotic bacterium. Microbiome 2023, 11 (1), 130.
Chan, W. C.; Trieger, K. A.; La Clair, J. J.; Jamieson, C. H. M.; Burkart, M. D., Stereochemical Control of Splice Modulation in FD-895 Analogues. J. Med. Chem. 2023, 66 (10), 6577-6590.
van der Werf, I. et al., Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells. Cell Rep. Med. 2023, 4 (3), 100962.
Crews, L. A. et al., Reversal of malignant ADAR1 splice isoform switching with Rebecsinib. Cell Stem Cell 2023, 30 (3), 250-263.e6.
Jiang, Z.; Chen, A.; Chen, J.; Sekhon, A.; Louie, G. V.; Noel, J. P.; La Clair, J. J.; Burkart, M. D., Masked cerulenin enables a dual-site selective protein crosslink. Chem. Sci. 2023, 14 (39), 10925-10933.
O'Herin, C. B.; Moriuchi, Y. W.; Bemis, T. A.; Kohlbrand, A. J.; Burkart, M. D.; Cohen, S. M., Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J. Med. Chem. 2023, 66 (4), 2789-2803.
Fischer, P. D. et al., Carrier protein mediated cargo sensing in quorum signal synthases. Chem. Commun. 2023, 59 (8), 1014-1017.
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2022
Gunawan, N. R. et al., Biodegradation of renewable polyurethane foams in marine environments occurs through depolymerization by marine microorganisms. Sci. Total Environ. 2022, 850, 158761.
Rajput, B. S., Hai, T. A. P., Burkart, M. D. High Bio-Content Thermoplastic Polyurethanes from Azelaic Acid. Molecules. 2022. 27 (15), 4885-4897.
Chen, A., Mindrebo, J. T., Davis, T. D., Kim, W. E., Katsuyama, Y., Jiang, Z., Ohnishi, Y., Noel, J. P., Burkart, M. D. Mechanism-based crosslinking probes capture E. coli ketosynthase FabB in conformationally-distinct catalytic states. Acta Crystallogr. D 2022, 78 (9), 1171-1179.
Corpuz, J. C., Sanlley, J. O., Burkart, M. D. Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains. Synth. Syst. Biotechnol. 2022, 7 (2), 677-688.
Kalaj, B. N., Ni, Q. Z., La Clair, J. J., Deheyn, D. D., Burkart, M. D. Chemoenzymatic Isolation and Characterization of High Purity Mammalian Melanin. ChemBioChem 2022, 23 (9), e202200021.
Bartholow, T. G., Sztain, T., Young, M. A., Lee, D. J., Davis, T. D., Abagyan, R., Burkart, M. D. Control of Unsaturation in De Novo Fatty Acid Biosynthesis by FabA. Biochemistry 2022, 61 (7), 608-615.
Chen, A., Jiang, Z., Burkart, M. D. Enzymology of standalone elongating ketosynthases. Chem. Sci. 2022, 13, 3225-4238.
Kim, W. E., Ishikawa, F., Re, R. N., Suzuki, T., Dohmae, N., Kakeya, H., Tanabe, G., Burkart, M. D. Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism. RSC Chem. Biol. 2022, 3, 312-319.
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2021
Mayfield, S., Burkart, M. D. The algae revolution 2.0: the potential of algae for the production of food, feed, fuel and bioproducts. Biochem. (Lond) 2021, 43 (6), 34-38.
Bemis, T. A., La Clair, J. J., Burkart, M. D. Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras. J. Med. Chem. 2021, 64 (12), 8042-8052.
Kim, W. E., Charov, K., Džunková, M. et al., Synthase-Selective Exploration of a Tunicate Microbiome by Activity-Guided Single-Cell Genomics. ACS Chem. Biol. 2021, 16 (5), 813-819.
Sztain, T., Bartholow, T. G., Lee, D. J., Casalino, L., Mitchell, A., Young, M. A., Wang, J., McCammon, J. A., Burkart, M. D. Decoding allosteric regulation by the acyl carrier protein. Proc. Natl. Acad. Sci. U. S. A. 2021, 118 (16), 1-7.
Hai, T. A. P., Tessman, M., Neelakantan, N., Samoylov, A. A., Ito, Y., Rajput, B. S., Pourahmady, N., Burkart, M. D. Renewable Polyurethanes from Sustainable Biological Precursors. Biomacromolecules 2021, 22 (5), 1770-1794.
Bartholow, T. G., Sztain, T., Patel, A., Lee, D. J., Young, M. A., Abagyan, R., Burkart, M. D. Elucidation of transient protein-protein interactions within carrier protein-dependent biosynthesis. Commun. Biol. 2021, 4 (1), 1-10.
Mindrebo, J. T., Chen, A., Kim, W. E., Re, R. N., Davis, T. D., Noel, J. P., Burkart, M. D. Structure and Mechanistic Analyses of the Gating Mechanism of Elongating Ketosynthases. ACS Catal. 2021, 11 (12), 6787-6799.
Khanal, S., Brea, R. J., Burkart, M. D., Deveraj, N. K. Chemoenzymatic Generation of Phospholipid Membranes Mediated by Type I Fatty Acid Synthase. J. Am. Chem. Soc. 2021, 143 (23), 8533-8537.
Cao, W., Zhou, X., McCallum, N. C. et al., Unraveling the Structure and Function of Melanin through Synthesis. J. Am. Chem. Soc. 2021, 143 (7), 2622-2637.
Bemis, T. A., La Clair, J. J., Burkart, M. D. Traceless Staudinger ligation enabled parallel synthesis of proteolysis targeting chimera linker variants. Chem. Comm. 2021, 57 (8), 1026-1029.
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2020
Chan, W. C., La Clair, J. J., León, B. et al., Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity. Cell Rep. Phys. Sci. 2020, 1 (12), 100277.
Misson, L. E., Mindrebo, J. T., Davis, T. D., Patel, A., McCammon, J. A., Noel, J. P., Burkart, M. D. Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (39), 24224-24233.
Du, D., Katsuyama, Y., Horiuchi, M., Fushinobu, S., Chen, A., Davis, T. D., Burkart, M. D., Ohnishi, Y. Structural basis for selectivity in a highly reducing type II polyketide synthase. Nat. Chem. Biol. 2020, 16, 776-782.
Mindrebo, J. T., Patel, A., Kim, W. E., Davis, T. D., Chen, A., Bartholow, T. G., La Clair, J. J., McCammon, J. A., Noel, J. P., Burkart, M. D. Gating mechanism of elongating β-ketoacyl-ACP synthases. Nat Commun. 2020, 11 (1), 1-15.
Trieger, K. A., La Clair, J. J., Burkart, M. D. Splice Modulation Synergizes Cell Cycle Inhibition. ACS Chem. Biol. 2020, 15 (3), 669-674.
Mindrebo, J. T., Misson, L. E., Johnson, C., Noel, J. P., Burkart, M. D. Activity Mapping the Acyl Carrier Protein - Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis. Biochemistry 2020, 59 (38), 3626-3638.
Hai, T. A. P., Neelakantan, N., Tessman, M., Sherman, S. D., Griffin, G., Pomeroy, R., Mayfield, S. P., Burkart, M. D. Flexible polyurethanes, renewable fuels, and flavorings from a microalgae oil waste stream. Green Chem. 2020, 22 (10), 3088-3094.
Corpuz, J. C., Podust, L. M., Davis, T. D., Jaremko, M. J., Burkart, M. D. Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis. RSC Chem. Biol. 2020, 1, 8-12.
Jaremko, M. J., Davis, T. D., Corpuz, J. C., Burkart, M. D. Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions. Nat. Prod. Rep. 2020, 37 (3), 355-379.
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2019
Pachiadaki, M. G. et al., Charting the complexity of the marine microbiome through single-cell genomics. Cell 2019, 179(7), 1623-1635.
Milligan, J. C., Lee, D. J., Jackson, D. R. et al., Molecular basis for interactions between an acyl carrier protein and a ketosynthase. Nat. Chem. Biol. 2019 15, 669-671.
Sztain, T., Patel, A., Lee, D. J., Davis, T. D., McCammon, J. A., Burkart, M. D. Modifying the thioester linkage affects the structure of the acyl carrier protein. Angew. Chem. Int. Ed. 2019 58, 10888-10892.
Dodge, G. J., Patel, A., Jaremko, K. L., McCammon, J. A., Smith, J. L., Burkart, M. D. Structural and dynamical rationale for fatty acid unsaturation in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 2019 116(14), 6775-6783.
Charov, K., Burkart, M. D. A single tool to monitor multiple protein-protein interactions of the Escherichia coli acyl carrier protein. ACS Infect. Dis. 2019 5(9), 1518-1523.
Kim, W. E., Patel, A., Hur, G. H., Tufar, P., Wuo, M. G., McCammon, J. A., Burkart, M. D. Mechanistic probes for the epimerization domain of nonribosomal peptide synthetases. Chembiochem 2019 20, 147-152.
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2018
Tallorin, L., Wang, J., Kim, W. E. et al., Discovering de novo peptide substrates for enzymes using machine learning. Nat Commun. 2018 9:5253.
Konno, S., La Clair, J. J., Burkart, M. D. Trapping the complex molecular machinery of polyketide and fatty acid synthases with tunable silylcyanohydrin crosslinkers. Angew. Chem. Int. Ed. 2018 57, 17009-17013.
Chen, A., Re, R. N., Burkart, M. D. Type II fatty acid and polyketide synthases: deciphering protein-protein and protein-substrate interactions. Nat Prod Rep. 2018 35, 1029-1045.
Michaud, J. M. et al., Taxon-specific aerosolization of bacteria and viruses in an experimental ocean-atmosphere mesocosm. Nat. Commun. 2018 9:2017.
Sarria, S., Bartholow, T. G., Verga, A., Burkart, M. D., Peralta-Yahya, P. Matching protein interfaces for improved medium-chain fatty acid production. ACS Synth. Biol. 2018 7(5), 1179-1187.
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2017
Jaremko, M. J., Lee, D. J., Patel, A. et al., Manipulating protein-protein interactions in nonribosomal peptide synthetase type II peptidyl carrier proteins. Biochemistry 2017 56(40), 5269-5273.
Barajas, J. F., Shakya, G., Moreno, G. et al., Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc. Natl. Acad. Sci. U. S. A. 2017 114(21), E4142-E4148.
León, B., Kashyap, M., Chan, W., Krug, K., Castro, J., La Clair, J. J., Burkart, M. D. A challenging pie to splice: Drugging the spliceosome. Angew. Chem. 2017 129, 12218-12230.
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2016
Crews, L. A., Balaian, L., Delos Santos, N. P. et al., RNA Splicing modulation selectivity impairs leukemia stem cell maintenance in secondary human AML. Cell Stem Cell 2016 19(5), 599-612.
Barajas, J. F., Finzel, K., Valentic, T. R. et al., Structural and biochemical analysis of protein-protein interactions between the acyl-carrier protein and product template domain. Angew. Chem. Int. Ed. 2016 55, 13005-13009.
Tallorin, L., Finzel, K., Nguyen, Q. G., Beld, J., La Clair, J. J., Burkart, M. D. Trapping of the enoyl-acyl carrier protein reductase–acyl carrier protein interaction. J. Am. Chem. Soc. 2016 138(12), 3962-3965.
Dhar, S., La Clair, J. J., León, B. et al., A carbohydrate-derived splice modulator. J. Am. Chem. Soc. 2016 138(15), 5063-5068.
Kumar, D., Kashyap, M. K., La Clair, J. J. et al., Selectivity in small molecule splicing modulation. ACS Chem. Biol. 2016 11(10), 2716-2723.
Finzel, K., Burkart, M. D. Traffic control in modular polyketide synthases. ACS Cent. Sci. 2016 2(1), 9-11.
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2015
Finzel, K., Nguyen, C., Jackson, D. R., Gupta, A., Tsai, S. C., Burkart, M. D. Probing the substrate specificity and protein-protein interactions of the E. coli fatty acid dehydratase, FabA. Chem. Biol. 2015 22, 1453-1460.
Jaremko, M. J., Lee, D. J., Opella, S. J., Burkart, M. D. Structure and substrate sequestration in the pyoluteorin type II peptidyl carrier protein PltL. J. Am. Chem. Soc. 2015 137(36), 11546-11549.
Kashyap, M. K., Kumar, D., Villa, R. et al., Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B. Haematologica 2015 100, 945-954.
Finzel, K., Lee, D. J., Burkart, M. D. Using modern tools to probe the structure–function relationship of fatty acid synthases. ChemBioChem 2015 16, 528-547.
Beld, J., Lee, D. J., Burkart, M. D. Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering. Mol. BioSyst. 2015 11, 38-59.
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2014
Nguyen, C., Haushalter, R. W., Lee, D. J. et al., Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature 2014 505, 427-431.
Beld, J., Sonnenschein, E. C., Vickery, C. R., Noel, J. P., Burkart, M. D. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat. Prod. Rep. 2014 31, 61-108.
Shakya, G., Rivera Jr., H., Lee, D. J. et al., Modeling linear and cyclic PKS intermediates through atom replacement. J. Am. Chem. Soc. 2014 136(48), 16792-16799.
Beld, J., Cang, H., Burkart, M. D. Visualizing the chain-flipping mechanism in fatty-acid biosynthesis. Angew. Chem. Int. Ed. 2014 53, 14456-14461.
Vickery, C. R., Kosa, N. M., Casavant, E. P., Duan, S., Noel, J. P., Burkart, M. D. Structure, biochemistry, and inhibition of essential 4′-phosphopantetheinyl transferases from two species of Mycobacteria. ACS Chem. Biol. 2014 9(9), 1939-1944.
Kosa, N. M., Pham, K. M., Burkart, M. D. Chemoenzymatic exchange of phosphopantetheine on protein and peptide. Chem. Sci. 2014 5, 1179-1186.
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2013
Ishikawa, F., Haushalter, R. W., Lee, D. J., Finzel, K., Burkart, M. D. Sulfonyl 3-alkynyl pantetheinamides as mechanism-based cross-linkers of acyl carrier protein dehydratase. J. Am. Chem. Soc. 2013 135(24), 8846-8849.
Villa, R., Kashyap, M. K., Kumar, D. et al., Stabilized cyclopropane analogs of the splicing inhibitor FD-895. J. Med. Chem. 2013 56(17), 6576-6582.
Rothmann, M., Kang, M., Villa, R. et al., Metabolic perturbation of an essential pathway: Evaluation of a glycine precursor of coenzyme A. J. Am. Chem. Soc. 2013 135(16), 5962-5965.
Burkart, M. D., Mayfield, S. P. Biofuels for the 21st century. Curr. Opin. Chem. Biol. 2013 17(3), 436-438.
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2012
Hur, G. H., Vickery, C. R., Burkart, M. D. Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology. Nat. Prod. Rep. 2012 29, 1074-1098.
Kosa, N. M., Haushalter, R. W., Smith, A. R., Burkart, M. D. Reversible labeling of native and fusion-protein motif. Nat. Methods 2012 9, 981-984.
Blatti, J. L., Beld, J., Behnke, C. A., Mendez, M., Mayfield, S. P., Burkart, M. D. Manipulating fatty acid biosynthesis in microalgae for biofuel through protein-protein interactions. PLoS One 2012 7(9): e42949.
Ishikawa, F., Haushalter, R. W., Burkart, M. D. Dehydratase-specific probes for fatty acid and polyketide synthases. J. Am Chem. Soc. 2012 134(2), 769-772.
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2003–2011
For publications from 2003–2011, please see Google Scholar or PubMed.