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2024
Jaisingh, A.; Halloran, M. W.; Rajput, B. S.; Burkart, M. D., Tailoring High Hardness and Rigidity in Biodegradable Thermoplastic Polyurethanes. ACS Appl. Polym. Mater. 2024, 6 (16), 9724-9734.
Jiang, Z.; Chen, J. A.; Mohamed, O. G.; Huynh, J.; Chen, A.; Tripathi, A.; La Clair, J. J.; Burkart, M. D., Cryptic Cerulenin Rearrangement in Ketosynthase Covalent Inhibition. J. Am. Chem. Soc. 2024, 146 (29), 20370-20378.
Miyada, M. G.; Choi, Y.; Stepanauskas, R.; Woyke, T.; La Clair, J. J.; Burkart, M. D., Fluorometric Analysis of Carrier-Protein-Dependent Biosynthesis through a Conformationally Sensitive Solvatochromic Pantetheinamide Probe. ACS Chem. Biol. 2024, 19 (7), 1416-1425.
Kalaj, B. N.; La Clair, J. J.; Shen, Y.; Schwieters, C. D.; Deshmukh, L.; Burkart, M. D., Quantitative Characterization of Chain-Flipping of Acyl Carrier Protein of Escherichia coli Using Chemical Exchange NMR. J. Am. Chem. Soc. 2024, 146 (27), 18650-18660.
Allemann, M. N.; Tessman, M.; Reindel, J.; Scofield, G. B.; Evans, P.; Pomeroy, R. S.; Burkart, M. D.; Mayfield, S. P.; Simkovsky, R., Rapid biodegradation of microplastics generated from bio-based thermoplastic polyurethane. Sci. Rep. 2024, 14 (1), 6036.
Bruckbauer, A.; Scofield, G. B.; Allemann, M. N.; Reindel, J.; Zhao, J.; Howell, A. N.; Frisch, T.; Johnson, L.; Evans, P.; Pomeroy, R. S.; Simkovsky, R.; Bae, J.; Mayfield, S. P.; Burkart, M. D., Renewable and Biodegradable Polyurethane Foams with Aliphatic Diisocyanates. Macromolecules 2024, 57 (6), 2879-2887.
Chen, A.; Re, R. N.; Davis, T. D.; Tran, K.; Moriuchi, Y. W.; Wu, S.; La Clair, J. J.; Louie, G. V.; Bowman, M. E.; Clarke, D. J.; Mackay, C. L.; Campopiano, D. J.; Noel, J. P.; Burkart, M. D., Visualizing the Interface of Biotin and Fatty Acid Biosynthesis through SuFEx Probes. J. Am. Chem. Soc. 2024, 146 (2), 1388-1395.
2023
Suo, Y.; Chen, A.; La Clair, J. J.; Burkart, M. D., Substrate Sequestration and Chain Flipping in Human Mitochondrial Acyl Carrier Protein. Biochem. 2023, 62 (24), 3548-3553.
Rajput, B. S.; Forman, A.; Halloran, M. W.; Hai, T. A. P.; Scofield, G. B.; Burkart, M. D., Variation of Aliphatic Diisocyanates in Bio-Based TPUs. Macromolecules 2023, 56 (21), 8813-8822.
Patel, A.; Rajput, B. S.; Hai, T. A. P.; Zhen, D.; Gunawan, N. R.; Tessman, M.; Reindel, J.; Shepherd, J.; Simkovsky, R.; Pomeroy, R. S.; Pourahmady, N.; Mayfield, S. P.; Burkart, M. D., Biodegradable waterborne polyurethane-urea dispersion adhesives with high biocontent. J. Appl. Polym. Sci. 2023, 140 (34), e54307.
Sztain, T.; Corpuz, J. C.; Bartholow, T. G.; Sanlley Hernandez, J. O.; Jiang, Z.; Mellor, D. A.; Heberlig, G. W.; La Clair, J. J.; McCammon, J. A.; Burkart, M. D., Interface Engineering of Carrier-Protein-Dependent Metabolic Pathways. ACS Chem. Biol. 2023, 18 (9), 2014-2022.
Halloran, M. W.; Hudecek, C.; Burkart, M. D., Synthesis of Acid Hydrazides from Carboxylic Acids in Continuous Flow. Org. Process Res. Dev. 2023, 27 (9), 1677-1683.
Džunková, M.; La Clair, J. J.; Tyml, T.; Doud, D.; Schulz, F.; Piquer-Esteban, S.; Porcel Sanchis, D.; Osborn, A.; Robinson, D.; Louie, K. B.; Bowen, B. P.; Bowers, R. M.; Lee, J.; Arnau, V.; Díaz-Villanueva, W.; Stepanauskas, R.; Gosliner, T.; Date, S. V.; Northen, T. R.; Cheng, J.-F.; Burkart, M. D.; Woyke, T., Synthase-selected sorting approach identifies a beta-lactone synthase in a nudibranch symbiotic bacterium. Microbiome 2023, 11 (1), 130.
Chan, W. C.; Trieger, K. A.; La Clair, J. J.; Jamieson, C. H. M.; Burkart, M. D., Stereochemical Control of Splice Modulation in FD-895 Analogues. J. Med. Chem. 2023, 66 (10), 6577-6590.
van der Werf, I.; Mondala, P. K.; Steel, S. K.; Balaian, L.; Ladel, L.; Mason, C. N.; Diep, R. H.; Pham, J.; Cloos, J.; Kaspers, G. J. L.; Chan, W. C.; Mark, A.; La Clair, J. J.; Wentworth, P.; Fisch, K. M.; Crews, L. A.; Whisenant, T. C.; Burkart, M. D.; Donohoe, M. E.; Jamieson, C. H. M., Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells. Cell Rep. Med. 2023, 4 (3), 100962.
Crews, L. A.; Ma, W.; Ladel, L.; Pham, J.; Balaian, L.; Steel, S. K.; Mondala, P. K.; Diep, R. H.; Wu, C. N.; Mason, C. N.; van der Werf, I.; Oliver, I.; Reynoso, E.; Pineda, G.; Whisenant, T. C.; Wentworth, P.; La Clair, J. J.; Jiang, Q.; Burkart, M. D.; Jamieson, C. H. M., Reversal of malignant ADAR1 splice isoform switching with Rebecsinib. Cell Stem Cell 2023, 30 (3), 250-263.e6.
Jiang, Z.; Chen, A.; Chen, J.; Sekhon, A.; Louie, Gordon V.; Noel, J. P.; La Clair, J. J.; Burkart, M. D., Masked cerulenin enables a dual-site selective protein crosslink. Chem. Sci. 2023, 14 (39), 10925-10933.
Crews, L. A.; Ma, W.; Ladel, L.; Pham, J.; Balaian, L.; Steel, S. K.; Mondala, P. K.; Diep, R. H.; Wu, C. N.; Mason, C. N.; van der Werf, I.; Oliver, I.; Reynoso, E.; Pineda, G.; Whisenant, T. C.; Wentworth, P.; La Clair, J. J.; Jiang, Q.; Burkart, M. D.; Jamieson, C. H. M., Reversal of malignant ADAR1 splice isoform switching with Rebecsinib. Cell Stem Cell 2023, 30 (3), 250-263.e6.
Varodayan, F. P.; Pahng, A. R.; Davis, T. D.; Gandhi, P.; Bajo, M.; Steinman, M. Q.; Kiosses, W. B.; Blednov, Y. A.; Burkart, M. D.; Edwards, S.; Roberts, A. J.; Roberto, M., Chronic ethanol induces a pro-inflammatory switch in interleukin-1β regulation of GABAergic signaling in the medial prefrontal cortex of male mice. Brain Behav. Immun. 2023, 110, 125-139.
O’Herin, C. B.; Moriuchi, Y. W.; Bemis, T. A.; Kohlbrand, A. J.; Burkart, M. D.; Cohen, S. M., Development of Human Carbonic Anhydrase II Heterobifunctional Degraders. J. Med. Chem. 2023, 66 (4), 2789-2803.
Cao, W.; Mao, H.; McCallum, N. C.; Zhou, X.; Sun, H.; Sharpe, C.; Korpanty, J.; Hu, Z.; Ni, Q. Z.; Burkart, M. D.; Shawkey, M. D.; Wasielewski, M. R.; Gianneschi, N. C., Biomimetic pheomelanin to unravel the electronic, molecular and supramolecular structure of the natural product. Chem. Sci. 2023, 14 (15), 4183-4192.
Fischer, P. D.; Chowdhury, A. S.; Bartholow, T.; Basu, S.; Baggs, E.; Cox, H. S.; Matošin, S.; Burkart, M. D.; Warner, L.; Nagarajan, R.; Arthanari, H., Carrier protein mediated cargo sensing in quorum signal synthases. Chem. Commun. 2023, 59 (8), 1014-1017.
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2022
Gunawan, N. R.; Tessman, M.; Zhen, D.; Johnson, L.; Evans, P.; Clements, S. M.; Pomeroy, R. S.; Burkart, M. D.; Simkovsky, R.; Mayfield, S. P., Biodegradation of renewable polyurethane foams in marine environments occurs through depolymerization by marine microorganisms. Sci. Total Environ. 2022, 850, 158761.
Van Der Werf, I.; Steel, K.; Mondala, P.; Balaian, L.; Cloos, J.; Kaspers, G. J. L.; La Clair, J.; Wentworth, P.; Fisch, K.; Crews, L.; Whisenant, T.; Burkart, M.; Donohoe, M.; Jamieson, C., Decreased Embryonic Splicing Repressor Expression Enhances Splicing Modulator Sensitivity in Pediatric Acute Myeloid Leukemia Stem Cells. Blood 2022, 140, 3354-3355.
Phung Hai, T. A.; Samoylov, A. A.; Rajput, B. S.; Burkart, M. D., Laboratory Ozonolysis Using an Integrated Batch–DIY Flow System for Renewable Material Production. ACS Omega 2022, 7 (18), 15350-15358.
Corpuz, J. C.; Patel, A.; Davis, T. D.; Podust, L. M.; McCammon, J. A.; Burkart, M. D., Essential Role of Loop Dynamics in Type II NRPS Biomolecular Recognition. ACS Chem. Biol. 2022, 17 (10), 2890-2898.
Rajput, B. S, Hai, T. A. P., Gunawan, N. R., Tessman, M., Neelakantan, N., Scofield, G. B., Brizuela, J., Samoylov, A. A., Modi, M., Shepherd, J., Patel, A., Pomeroy, R. S., Pourahmady, N., Mayfield, S. P., Burkart, M. D. Renewable Low Viscosity Polyester-Polyols for Biodegradable Thermoplastic Polyurethanes. J. Appl. Polym. Sci. 2022, 1-14.
Rajput, B. S., Hai, T. A. P., Burkart, M. D. High Bio-Content Thermoplastic Polyurethanes from Azelaic Acid. Molecules. 2022. 27 (15), 4885-4897.
Chen, A., Mindrebo, J. T., Davis, T. D., Kim, W. E., Katsuyama, Y., Jiang, Z., Ohnishi, Y., Noel, J. P., Burkart, M. D. Mechanism-based crosslinking probes capture E. coli ketosynthase FabB in conformationally-distinct catalytic states. Acta Crystallogr. D 2022, 78 (9), 1171-1179.
Corpuz, J. C., Sanlley, J. O., Burkart, M. D. Protein-protein interface analysis of the non-ribosomal peptide synthetase peptidyl carrier protein and enzymatic domains. Synth. Syst. Biotechnol. 2022, 7 (2), 677-688.
Kalaj, B. N., Ni, Q. Z., La Clair, J. J., Deheyn, D. D., Burkart, M. D. Chemoenzymatic Isolation and Characterization of High Purity Mammalian Melanin. ChemBioChem 2022, 23 (9), e202200021.
Hai, T. A. P., Samoylov, A. A., Rajput, B. S., Burkart, M. D. Laboratory Ozonolysis Using an Integrated Batch–DIY Flow System for Renewable Material Production. ACS Omega 2022, 7 (18), 15350-15358.
Kumar, D., Kashyap, M. K., Yu, Z., Spaanderman, I., Villa, R., Kipps, T. J., La Clair, J. J., Burkart, M. D., Castro, J. E. Modulation of RNA splicing associated with Wnt signaling pathway using FD-895 and pladienolide B. Aging (Albany NY) 2022, 14 (5), 2081-2100.
Bartholow, T. G., Sztain, T., Young, M. A., Lee, D. J., Davis, T. D., Abagyan, R., Burkart, M. D. Control of Unsaturation in De Novo Fatty Acid Biosynthesis by FabA. Biochemistry 2022, 61 (7), 608-615.
Chen, A., Jiang, Z., Burkart, M. D. Enzymology of standalone elongating ketosynthases. Chem. Sci. 2022, 13, 3225-4238.
Kim, W. E., Ishikawa, F., Re, R. N., Suzuki, T., Dohmae, N., Kakeya, H., Tanabe, G., Burkart, M. D.
Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism. RSC Chem. Biol. 2022, 3, 312-319.
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2021
Mayfield, S., Burkart, M. D. The algae revolution 2.0: the potential of algae for the production of food, feed, fuel and bioproducts – why we need it now. Biochem. (Lond) 2021, 43 (6), 34-38.
Singla, S., Htut, K. Z., Zhu, R., Davis, A., Ma, J., Ni, Q. Z., Burkart, M. D., Maurer, C., Miyoshi, T., Dhinojwala, A. Isolation and Characterization of Allomelanin from Pathogenic Black Knot Fungus─a Sustainable Source of Melanin. ACS Omega 2021, 6 (51), 35514-35522.
Crews, L. A., Mondala, P., Mason, C., Balaian, L., Ma, W., Pham, J., Wu, C., Wentworth, P., La Clair, J. J., Burkart, M. D., Jamieson, C. ADAR1 Splicing Modulation As a Mechanism to Eradicate Immunologically Silent Leukemia Stem Cells. Blood 2021, 138, 3321.
Mondala, P., Van Der Werf, I., Balaian, L., Steel, K., Ladel, L., Mason, C., Diep, R., Cloos, J., Kaspers, G., van Roosmalen, M. J., Van Boxtel, R., Chan, W., Mark, A., Donohoe, M., La Clair, J. J., Wentworth, P., Fisch, K., Crews, L. A., Whisenant, T., Burkart, M. D., Jamieson, C. Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells. Blood 2021, 138, 2227.
Beall, C. M., Michaud, J. M., Fish, M. A., Dinasquet, J., Cornwell, G. C., Stokes, M. D., Burkart, M. D., Hill, T. C., DeMott, P. J., Prather, K. A. Cultivable halotolerant ice-nucleating bacteria and fungi in coastal precipitation. Atmos. Chem. Phys. 2021, 21, 9031-9045.
Bemis, T. A., La Clair, J. J., Burkart, M. D. Unraveling the Role of Linker Design in Proteolysis Targeting Chimeras. J. Med. Chem. 2021, 64 (12), 8042-8052.
Fields, F. J., Hernandez, R. E., Weilbacher, E., Garcia-Vargas, E., Huynh, J., Thurmond, M., Lund, R., Burkart, M. D., Mayfield, S. P. Annual productivity and lipid composition of native microalgae (Chlorophyta) at a pilot production facility in Southern California. Algal Res. 2021, 56, 102307.
Hong, K., Beld, J., Davis, T. D., Burkart, M. D., Palenik, B. Screening and characterization of polyhydroxyalkanoate granules, and phylogenetic analysis of polyhydroxyalkanoate synthase gene PhaC in cyanobacteria. J. Phycol. 2021, 57 (3), 754-765.
Kim, W. E., Charov, K., Džunková, M., Becraft, E. D., Brown, J., Schulz, F., Woyke, T., La Clair, J. J., Stepanauskas, R., Burkart, M. D. Synthase-Selective Exploration of a Tunicate Microbiome by Activity-Guided Single-Cell Genomics. ACS Chem. Biol. 2021, 16 (5), 813-819.
Charov, K., Bukart, M. D. In silico identification and in vitro evaluation of a protein-protein interaction inhibitor of Escherichia coli fatty acid biosynthesis. Chem. Biol. Drug Des. 2021, 98 (1), 94-101.
Sztain, T., Bartholow, T. G., Lee, D. J., Casalino, L., Mitchell, A., Young, M. A., Wang, J., McCammon, J. A., Burkart, M. D. Decoding allosteric regulation by the acyl carrier protein. Proc. Natl. Acad. Sci. U. S. A. 2021, 118 (16), 1-7.
Hai, T. A. P., Tessman, M., Neelakantan, N., Samoylov, A. A., Ito, Y., Rajput, B. S., Pourahmady, N., Burkart, M. D. Renewable Polyurethanes from Sustainable Biological Precursors. Biomacromolecules 2021, 22 (5), 1770-1794.
Bartholow, T. G., Sztain, T., Patel, A., Lee, D. J., Young, M. A., Abagyan, R., Burkart, M. D. Elucidation of transient protein-protein interactions within carrier protein-dependent biosynthesis. Commun. Biol. 2021, 4 (1), 1-10.
Xie, Y., Krug, K. A., Cay, K. S., Kalaj, M., McCallum, N. C., Siwicka, Z. E., Wang, Z., Gianneschi, N. C., Burkart, M. D., Rinehart, J. D. Peroxidase-Like Reactivity at Iron-Chelation Sites in a Mesoporous Synthetic Melanin. CCS Chem. 2021, 3 (3), 1483-1490.
Mindrebo, J. T., Chen, A., Kim, W. E., Re, R. N., Davis, T. D., Noel, J. P., Burkart, M. D. Structure and Mechanistic Analyses of the Gating Mechanism of Elongating Ketosynthases. ACS Catal. 2021, 11 (12), 6787-6799.
Bartholow, T. G., Sztain, T., Young, M. A., Davis, T. D., Abagyan, R., Burkart, M. D. Protein–protein interaction based substrate control in the E. coli octanoic acid transferase, LipB. RSC Chem. Biol. 2021, 2, 1466-1473.
Khanal, S., Brea, R. J., Burkart, M. D., Deveraj, N. K. Chemoenzymatic Generation of Phospholipid Membranes Mediated by Type I Fatty Acid Synthase. J. Am. Chem. Soc. 2021, 143 (23), 8533-8537.
Cao, W., Zhou, X., McCallum, N. C., Hu, Z., Ni, Q. Z., Kapoor, U., Heil, C. M., Cay, K. S., Zand, T., Mantanona, A. J., Jayaraman, A., Dhinojwala, A., Deheyn, D. D., Shawkey, M. D., Burkart, M. D., Rinehart, J. D., Gianneschi, N. C. Unraveling the Structure and Function of Melanin through Synthesis. J. Am. Chem. Soc. 2021, 143 (7), 2622-2637.
Hu, Z., Sun, H., Thompson, M. P., Xiao, M., Allen, M. C., Zhou, X., Ni, Q. Z., Wang, Z., Li, W., Burkart, M. D., Deheyn, D. D., Dhinojwala, A., Shawkey, M. D., Gianneschi, N. C. Structurally Colored Inks from Synthetic Melanin-Based Crosslinked Supraparticles. ACS Materials Lett. 2021, 3 (1), 50-55.
Bemis, T. A., La Clair, J. J., Burkart, M. D. Traceless Staudinger ligation enabled parallel synthesis of proteolysis targeting chimera linker variants. Chem. Comm. 2021, 57 (8), 1026-1029.
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2020
Chan, W. C., La Clair, J. J., León, B., Trieger, K. A., Slagt, M. Q., Verhaar, M. T., Bachera, D. U., Rispens, M. T., Hofman, R. M., de Boer, V. L., van der Hulst, R., Bus, R., Hiemstra, P, Neville, M. L., Mandla, K. A., Figueroa, J. S., Jamieson, C., Burkart, M. D. Scalable Synthesis of 17S-FD-895 Expands the Structural Understanding of Splice Modulatory Activity. Cell Rep. Phys. Sci. 2020, 1 (12), 100277.
Hong, K., Beld, J., Davis, T. D., Burkart, M. D., Palenik, B. Screening and characterization of polyhydroxyalkanoate granules, and phylogenetic analysis of polyhydroxyalkanoate synthase gene PhaC in cyanobacteria. J. Phycol. 2020, TBD
Battistella, C., McCallum, N. C., Vanthournout, B., Forman, C. J., Ni, Q. Z., La Clair, J. J., Burkart, M. D., Shawkey, M. D., Gianneschi, N. C. Bioinspired chemoenzymatic route to artificial melanin for hair pigmentation. Chem. Mater. 2020, 32 (21), 9201-9210.
Misson, L. E., Mindrebo, J. T., Davis, T. D., Patel, A., McCammon, J. A., Noel, J. P., Burkart, M. D. Interfacial plasticity facilitates high reaction rate of E. coli FAS malonyl-CoA:ACP transacylase, FabD. Proc. Natl. Acad. Sci. U. S. A. 2020, 117 (39), 24224-24233.
Xie, Y., Krug, K. A., Cay, K. S., Kalaj, M., McCallum, N. C., Siwicka, Z. E., Wang, Z., Gianneschi, N. C., Burkart, M. D., Rinehart, J. D. Peroxidase-like reactivity at iron-chelation sites in a mesoporous synthetic melanin. CCS Chemistry 2020, 1483-1490.
Subramanian, R. H., Suzuki, Y., Tallorin, L., Sahu, S., Thompson, M., Gianneschi, N. C., Burkart, M. D., Tezcan, F. A. Enzyme-Directed Functionalization of Designed, Two-Dimensional Protein Lattices. Biochemistry 2020, TBD
Gunawan, N. R., Tessman, M., Schreiman, A. C., Simkovsky, R., Samoylov, A. A., Neelakantan, N. K., Bemis, T. A., Burkart, M. D., Pomeroy, R. S., Mayfield, S. P. Rapid biodegradation of renewable polyurethane foams with identification of associated microorganisms and decomposition products. Bioresour. Technol. 2020, 11, 100513.
Cao, W., McCallum, N. C., Ni, Q. Z., Li, W., Boyce, H., Mao, H., Zhou, X., Sun, H., Thompson, M. P., Battistella, C., Wasielewski, M. R., Dhinojwala, A., Shawkey, M. D., Burkart, M. D., Wang, Z., Gianneschi, N. C. Selenomelanin: An Abiotic Selenium Analogue of Pheomelanin. J. Am. Chem. Soc. 2020, 142 (29), 12802-12810.
Hai, T. A. P., De Backer, L. J. S., Cosford, N. D. P., Burkart, M. D. Preparation of Mono- and Diisocyanates in Flow from Renewable Carboxylic Acids. Org. Process Res. Dev. 2020, 24 (10), 2342-2346.
Du, D., Katsuyama, Y., Horiuchi, M., Fushinobu, S., Chen, A., Davis, T. D., Burkart, M. D., Ohnishi, Y. Structural basis for selectivity in a highly reducing type II polyketide synthase. Nat. Chem. Biol. 2020, 16, 776-782.
Charov, K., Burkart, M. D. Quantifying protein-protein interactions of the acyl carrier protein with solvatochromic probes. Meth. Enzymol. 2020, 638, 321-340
Mindrebo, J. T., Patel, A., Kim, W. E., Davis, T. D., Chen, A., Bartholow, T. G., La Clair, J. J., McCammon, J. A., Noel, J. P., Burkart, M. D. Gating mechanism of elongating β-ketoacyl-ACP synthases. Nat Commun. 2020, 11 (1), 1-15
Trieger, K. A., La Clair, J. J., Burkart, M. D. Splice Modulation Synergizes Cell Cycle Inhibition. ACS Chem. Biol. 2020, 15 (3), 669-674.
Vickery, C. R., McCulloch, I. P., Sonnenschein, E. C., Beld, J., Noel, J. P., Burkart, M. D. Dissecting modular synthases through inhibition: A complementary chemical and genetic approach. bioorg. Med. Chem. Lett. 2020, 30 (2), 126820
Mindrebo, J. T., Misson, L. E., Johnson, C., Noel, J. P., Burkart, M. D. Activity Mapping the Acyl Carrier Protein - Elongating Ketosynthase Interaction in Fatty Acid Biosynthesis. Biochemistry 2020, 59 (38), 3626-3638.
Ni, Q. Z., Sierra, B. N., La Clair, J. J., Burkart, M. D. Chemoenzymatic elaboration of the Raper–Mason pathway unravels the structural diversity within eumelanin pigments. Chem. Sci. 2020, 11, 7836-7841.
Hai, T. A. P., Neelakantan, N., Tessman, M., Sherman, S. D., Griffin, G., Pomeroy, R., Mayfield, S. P., Burkart, M. D. Flexible polyurethanes, renewable fuels, and flavorings from a microalgae oil waste stream. Green Chem. 2020, 22 (10), 3088-3094.
Corpuz, J. C., Podust, L. M., Davis, T. D., Jaremko, M. J., Burkart, M. D. Dynamic visualization of type II peptidyl carrier protein recognition in pyoluteorin biosynthesis. RSC Chem. Biol. 2020, 1, 8-12.
Jaremko, M. J., Davis, T. D., Corpuz, J. C., Burkart, M. D. Type II non-ribosomal peptide synthetase proteins: structure, mechanism, and protein-protein interactions. Nat. Prod. Rep. 2020, 37 (3), 355-379.
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2019
Pachiadaki, M. G., Brown, J. M., Brown, J., Bezuidt, O., Berube, P. M., Biller, S. J., Poulton, N. J., Burkart, M. D., La Clair, J. J., Chisholm, S. W., & Stepanauskas, R. Charting the complexity of the marine microbiome through single-cell genomics. Cell 2019, 179(7), 1623-1635.
Bajo, M., Patel, R. R., Hedges, D. M., Varodayan, F. P., Vlkolinsky, R., Davis, T. D., Burkart, M. D., Blednov, Y. A., Roberto, M. Role of MyD88 in IL-1β and ethanol modulation of GABAergic transmission in the central amygdala. Brain Sci. 2019, 9(12), 361.
Re, R. N., Proessdorf, J. C., La Clair, J. J., Subileau, M., Burkart, M. D. Tailoring chemoenzymatic oxidation via in situ peracids. Org. Biomol. Chem. 2019, 17(43), 9418-9424.
Sztain, T., Bartholow, T. G., McCammon, J. A., & Burkart, M. D. Shifting the hydrolysis equilibrium of substrate loaded acyl carrier proteins. Biochemistry 2019 58(34), 3557-3560.
Xie, Y., Wang, J., Wnag, J., Hu, Z., Hariri, A., Tu, N., Krug, K. A., Burkart, M. D., Gianneschi, N. C., Jokerst, J. V., & Rinehart, J. D. Tuning the ultrasonic and photoacoustic response of polydopamine-stabilized perfluorocarbon contrast agents. J. Mater. Chem. B. 2019 7(31), 4833-4842.
Callmann, C. E., LeGuyader, C. L. M., Burton, S. T., Thompsn, M. P., Hennis, R., Barback, C., Henriksen, N. M., Chan, W. C., Jaremko, M. J., Yang, J., Garcia, A., Burkart, M. D., Gilson, M. K., Momper, J. D., Bertin, P. A., & Gianneschi, N. C. Antitumor activity of 1, 18-octadecanedioic acid-paclitaxel complexed with human serum albumin. J. Am. Chem. Soc. 2019 141(30), 11765-11769.
Charov, K., & Burkart, M. D. A single tool to monitor multiple protein-protein interactions of the Escherichia coli acyl carrier protein. ACS Infect. Dis. 2019 5(9), 1518-1523.
Milligan, J. C., Lee, D. J., Jackson, D. R., Schaub, A. J., Beld, J., Barajas, J. F., Hale, J. J., Luo, R., Burkart, M. D., & Tsai, S. C. Molecular basis for interactions between an acyl carrier protein and a ketosynthase. Nat. Chem. Biol. 2019 15, 669-671.
Sztain, T., Patel, A., Lee, D. J., Davis, T. D., McCammon, J. A., & Burkart, M. D. Modifying the thioester linkage affects the structure of the acyl carrier protein. Angew. Chem. Int. Ed. 2019 58, 10888-10892.
Davis, T. D., Michaud, J. M., & Burkart, M. D. Active site labeling of fatty acid and polyketide acyl-carrier protein transacylases. Org. Biomol.Chem. 2019
Dodge, G. J., Patel, A., Jaremko, K. L., McCammon, J. A., Smith, J. L., & Burkart, M. D. Structural and dynamical rationale for fatty acid unsaturation in Escherichia coli. Proc. Natl. Acad. Sci. U. S. A. 2019 116(14), 6775-6783.
Kim, W. E., Patel, A., Hur, G. H., Tufar, P., Wuo, M. G., McCammon, J. A., & Burkart, M. D. Mechanistic probes for the epimerization domain of nonribosomal peptide synthetases. Chembiochem 2019 20, 147-152.
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2018
Tallorin, L., Wang, J., Kim, W. E., Sahu, S., Kosa, N. M., Yang, P., Thompson, M., Gilson, M. K., Frazier, P. I., Burkart, M. D., & Gianneschi, N. C. Discovering de novo peptide substrates for enzymes using machine learning. Nat Commun. 2018 9:5253.
Chan, W. C., León B., Krug, K. A., Patel, A., La Clair, J. J., & Burkart, M. D. Daedal facets of splice modulator optimization. ACS Med. Chem. Lett. 2018 9(11), 1070-1072.
Konno, S., La Clair, J. J., & Burkart, M. D. Trapping the complex molecular machinery of polyketide and fatty acid synthases with tunable silylcyanohydrin crosslinkers. Angew. Chem. Int. Ed. 2018 57, 17009-17013.
Chen, A., Re, R. N., & Burkart, M. D. Type II fatty acid and polyketide synthases: deciphering protein-protein and protein-substrate interactions. Nat Prod Rep. 2018 35, 1029-1045.
Roulet, J., Taton, A., Golden, J. W., Arabolaza, A., Burkart, M. D., & Gramajo, H. Development of a cyanobacterial heterologous polyketide production platform. Metab. Eng. 2018 49, 94-104.
Michaud, J. M., Thompson, L. R., Kaul, D., Espinoza, J. L., Richter, R. A., Xu, Z. Z., Lee, C., Pham, K. M., Beall, C. M., Malfatti, F., Azam, F., Knight, R., Burkart, M. D., Dupont, C. L., & Prather, K. A. Taxon-specific aerosolization of bacteria and viruses in an experimental ocean-atmosphere mesocosm. Nat. Commun. 2018 9:2017
Sarria, S., Bartholow, T. G., Verga, A., Burkart, M. D., & Peralta-Yahya, P. Matching protein interfaces for improved medium-chain fatty acid production. ACS Synth. Biol. 2018 7(5), 1179-1187.
Davis, T. D., Kunakom, S., Burkart, M. D., & Eustaquio, A. S. Preparation, assay, and application of chlorinase SalL for the chemoenzymatic synthesis of S-adenosyl-L-methionine and analogs. Method Enzymol. 2018 604, 367-388.
Vickery, C. R., Cardenas, J., Bowman, M. E., Burkart, M. D., Da Silva, N. A., & Noel, J. P. A coupled in vitro/in vivo approach for engineering a heterologous type III PKS to enhance polyketide biosynthesis in Saccaromyces cerevisiae. Biotechnol. Bioeng. 2018 115, 1394-1402.
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2017
Konno, S., Misson, L., & Burkart, M. D. Thioesterase domain-mediated macrocyclization of non-ribosomal peptides. Cyclic Peptides: From Bioorganic Synthesis to Applications. RSC 2017 Chapter 3, 33-55
Jaremko, M. J., Lee, D. J., Patel, A., Winslow, V., Opella, S. J., McCammon, J. A., & Burkart, M. D. Manipulating protein-protein interactions in nonribosomal peptide synthetase type II peptidyl carrier proteins. Biochemistry 2017 56(40), 5269-5273.
Szyjka, S. J., Mandal, S., Schoepp, N. G., Tyler, B. M., Yohn, C. B., Poon, Y. S., Vilareal, S., Burkart, M. D., Shurin, J. B. & Mayfield, S. P. Evaluation of phenotype stability and ecological risk of a genetically engineered alga in open pond production. Algal Research 2017 24, 378-386.
Barajas, J. F., Shakya, G., Moreno, G., Rivera Jr., H., Jackson, D. R., Topper, C. L., Vagstad, A. L., La Clair, J. J., Townsend, C. A., Burkart, M. D., & Tsai, S. C. Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases. Proc. Natl. Acad. Sci. U. S. A. 2017 114(21), E4142-E4148.
León, B., Kashyap, M., Chan, W., Krug, K., Castro, J., La Clair, J. J., Burkart, M. D. A challenging pie to splice: Drugging the spliceosome. Angew. Chem. 2017 129, 12218-12230.
Finzel, K., Beld, J., Burkart, M. D., & Charkoudian, L. K. Utilizing mechanistic cross-linking technology to study protein-protein interations: An experiment designed for an undergraduate biochemistry lab. J. Chem. Educ. 2017 94(3), 375-379.
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2016
Mindrebo, J. T., Nartey, C. M., Seto, Y., Burkart, M. D., & Noel, J. P. Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom. Curr. Opin. Struc. Biol. 2016 Volume 41, 233-246.
Crews, L. A., Balaian, L., Delos Santos, N. P., Leu, H. S., Court, A. C., Lazzari, E., Sadarangani, A., Zipeto, M. A., La Clair, J. J., Villa, R., Kulidjian, A., Storb, R., Morris, S. R., Ball, E. D., Burkart, M. D., & Jamieson, C. H. M. RNA Splicing modulation selectivity impairs leukemia stem cell maintenance in secondary human AML. Cell Stem Cell 2016 19(5), 599-612.
Shurin, J. B., Burkart, M. D. Mayfield, S. P., & Smith, V. H. Recent progress and future challenges in algal biofuel production. F1000Research 2016 5 (F1000 Faculty Rev):2434.
Barajas, J. F., Finzel, K., Valentic, T. R., Shakya, G., Gamarra, N., Martinez, D., Meier, J. L., Vagstad, A. L., Newman, A. G., Townsend, C. A., Burkart, M. D. & Tsai, S. C. Structural and biochemical analysis of protein-protein interactions between the acyl-carrier protein and product template domain. Angew. Chem. Int. Ed. 2016 55, 13005-13009.
McCulloch, I. P., La Clair, J. J., Jaremko, M. J., & Burkart, M. D. Fluorescent mechanism-based probe for aerobic flavin-dependent enzyme activity. ChemBioChem 2016 17, 1598-1601.
Kumar, D., Kashyap, M. K., La Clair, J. J., Villa, R., Spaanderman, I., Chien, S., Rassenti, L. Z., Kipps, T. J., Burkart, M. D., & Castro, J. E. Selectivity in small molecule splicing modulation. ACS Chem. Biol. 2016 11(10) 2716-2723.
Foley, T. L., Dorjsuren, D., Dexheimer, T. S., Burkart, M. D., Wight, W. C., & Simeonov, A. A platform to enable the pharmacological profiling of small molecules in gel-based electrophoretic mobility shift assays. J. Biomol. Screen. 2016 vol. 21(10), 1125-1131.
Koo, H. J., Vickery, C. R., Xu, Y., Louie, G. V., O'Maille, P. E., Bowman, M., Nartey, C. M., Burkart, M. D. & Noel, J. P. Biosynthetic potential of sesquiterpene synthases: Product profiles of Egyptian Henbane premnaspirodiene synthase and related mutants. J. Antibiot. 2016 69, 524-533.
Uranga, C. C., Beld, J., Mrse, A., Córdova-Guerrero, I., Burkart, M. D. & Hernández-Martínez, R. Data from mass spectrometry, NMR spectra, GC-MS of fatty acid esters produced by Lasiodiplodia theobromae. Data in Brief 2016 8, 31-39.
Uranga, C. C., Beld, J., Mrse, A., Córdova-Guerrero, I., Burkart, M. D. & Hernández-Martínez, R. Fatty acid esters produced by Lasiodiplodia theobromae function as growth regulators in tobacco seedlings. Biochem. Bioph. Res. Co. 2016 472(2), 339-345.
Finzel, K., & Burkart, M. D. Traffic control in modular polyketide synthases. ACS Cent. Sci. 2016 2(1), 9-11.
Dhar, S., La Clair, J. J., León, B., Hammons, J. C., Yu, Z., Kashyap, M. K., Castro, J. E., & Burkart, M. D. A carbohydrate-derived splice modulator. J. Am. Chem. Soc. 2016 138(15), 5063–5068.
Rivera Jr., H., Dhar, S., La Clair, J. J., Tsai, S. C., & Burkart, M. D. An unusual intramolecular trans-amidation. Tetrahedron 2016 72(25), 3605-3608.
Tallorin, L., Finzel, K., Nguyen, Q. G., Beld, J., La Clair, J. J., & Burkart, M. D. Trapping of the enoyl-acyl carrier protein reductase–acyl carrier protein interaction. J. Am. Chem. Soc. 2016 138(12), 3962-3965.
Beld, J., Abbriano, R., Finzel, K., Hildebrand, M., & Burkart, M. D. Probing fatty acid metabolism in bacteria, cyanobacteria, green microalgae and diatoms with natural and unnatural fatty acids. Mol. BioSyst. 2016 12, 1299-1312.
Patterson, J. P., Collins, D. B., Michaud, J. M., Axson, J. L., Sultana, C. M., Moser, T., Dommer, A. C., Conner, J., Grassian, V. H., Stokes, M. D., Deane, G. B., Evans, J. E., Burkart, M. D., Prather, K. A., & Gianneschi, N. C. Sea spray aerosol structure and composition using cryogenic transmission electron microscopy. ACS Cent. Sci. 2016 2(1), 40–47.
Vickery, C. R., La Clair, J. J., Burkart, M. D., & Noel, J. P. Harvesting the biosynthetic machineries that cultivate a variety of indispensable plant natural products. Curr. Opin. Chem. Biol. 2016 31, 66-73.
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2015
Moynié, L., Hope, A. G., Finzel, K., Schmidberger, J., Leckie, S. M., Schneider, G., Burkart, M. D., Smith, A. D., Gray, D. W. & Naismith, J. H. A substrate mimic allows high-throughput assay of the FabA protein and consequently the identification of a novel inhibitor of Pseudomonas aeruginosa FabA. J. Mol. Biol. 2015 428, 108-120.
Finzel, K., Nguyen, C., Jackson, D. R., Gupta, A., Tsai, S. C., & Burkart, M. D. Probing the substrate specificity and protein-protein interactions of the E. coli fatty acid dehydratase, FabA. Chem. Biol. 2015 22, 1453-1460.
Jaremko, M. J., Lee, D. J., Opella, S. J., & Burkart, M. D. Structure and substrate sequestration in the pyoluteorin type II peptidyl carrier protein PltL. J. Am. Chem. Soc. 2015 137(36), 11546-11549.
Lin, L., Nonejuie, P., Munguia, J., Hollands, A., Olson, J., Dam, Q., Kumaraswamy, M., Rivera Jr., H., Corriden, R., Rohde, M., Hensler, M. E., Burkart, M. D., Pogliano, J., Sakoulas, G., & Nizet, V. Azithromycin synergizes with cationic antimicrobial peptides to exert bactericidal and therapeutic activity against highly multidrug-resistant gram-negative bacterial pathogens. EBioMedicine 2015 2, 690-698.
Cahill, J. F., Darlington, T. K., Fitzgerald, C., Schoepp, N. G., Beld, J., Burkart, M. D., & Prather, K. A. Online analysis of single cyanobacteria and algae cells under nitrogen-limited conditions using aerosol time-of-flight mass spectrometry. Anal. Chem. 2015 87(16), 8039-8046.
Ferreira-Camargo, L. S., Tran, M., Beld, J., Burkart, M. D., & Mayfield, S. P. Selenocystamine improves protein accumulation in chloroplasts of eukaryotic green algae. AMB Express 2015 5:39.
Kashyap, M. K., Kumar, D., Villa, R., La Clair, J. J., Benner, C., Sasik, R., Jones, H., Ghia, E. M., Rassenti, L. Z., Kipps, T. J., Burkart, M. D. & Castro, J. E. Targeting the spliceosome in chronic lymphocytic leukemia with the macrolides FD-895 and pladienolide-B. Haematologica 2015 100, 945-954.
Konno, S., Ishikawa, F., Suzuki, T., Dohmae, N., Burkart, M. D., & Kakeya, H. Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases. Chem. Commun. 2015 51, 2262-2265.
Finzel, K., Lee, D. J., & Burkart, M. D. Using modern tools to probe the structure–function relationship of fatty acid synthases. ChemBioChem 2015 16, 528-547.
Beld, J., Lee, D. J., & Burkart, M. D. Fatty acid biosynthesis revisited: structure elucidation and metabolic engineering. Mol. BioSyst. 2015 11, 38-59.
Lindert, S., Tallorin, L., Nguyen, Q. G., Burkart, M. D., & McCammon, J. A. In silico screening for Plasmodium falciparum enoyl-ACP reductase inhibitors. J. Comput. Aid. Mol. Des. 2015 29(1), 79-87.
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2014
Ku, T. H., Sahu, S., Kosa, N. M., Pham, K. M., Burkart, M. D., & Gianneschi, N. C. Tapping a bacterial enzymatic pathway for the preparation and manipulation of synthetic nanomaterials. J. Am. Chem. Soc. 2014 136(50), 17378-17381.
Shakya, G., Rivera Jr., H., Lee, D. J., Jaremko, M. J., La Clair, J. J., Fox, D. T., Haushalter, R. W., Schaub, A. J., Bruegger, J., Barajas, J.F., White, A. R., Kaur, P., Gwozdziowski, E. R., Wong, F., Tsai, S. C., & Burkart, M. D. Modeling linear and cyclic PKS intermediates through atom replacement. J. Am. Chem. Soc. 2014 136(48), 16792-16799.
Beld, J., Cang, H., & Burkart, M. D. Visualizing the chain‐flipping mechanism in fatty‐acid biosynthesis. Angew. Chem. Int. Ed. 2014 53, 14456-14461.
Beld, J., Finzel, K., & Burkart, M. D. Versatility of acyl-acyl carrier protein synthetases. Chem. Biol. 2014 21(10), 1293-1299.
Tallorin, L., Durrant, J. D., Nguyen, Q. G., McCammon, J. A., & Burkart, M. D. Celastrol inhibits Plasmodium falciparum enoyl-acyl carrier protein reductase. Bioorgan. Med. Chem. 2014 22(21), 6053-6061.
Beld, J., Blatti, J. L., Behnke, C., Mendez, M., & Burkart, M. D. Evolution of acyl-ACP thioesterases and β-ketoacyl-ACP synthases revealed by protein–protein interactions. J. Appl. Phycol. 2014 26, 1619-1629.
Schoepp, N. G., Stewart, R. L., Sun, V., Quigley, A. J., Mendola, D., Mayfield, S. P., & Burkart, M. D. System and method for research-scale outdoor production of microalgae and cyanobacteria. Bioresource Technol. 2014 166, 273-281.
Bruegger, J., Caldara, G., Beld, J., Burkart, M. D., & Tsai, S. C. Polyketide synthase: Sequence, structure, and function. Natural Products: Discourse, Diversity, and Design. Wiley & Sons, Inc. 2014 Chapter 12, 219-243.
Vickery, C. R., Kosa, N. M., Casavant, E. P., Duan, S., Noel, J. P., & Burkart, M. D. Structure, biochemistry, and inhibition of essential 4´-phosphopantetheinyl transferases from two species of Mycobacteria. ACS Chem. Biol. 2014 9(9), 1939-1944.
Rothmann, M., Kosa, N. M., & Burkart, M. D. Resin supported acyl carrier protein labeling strategies. RSC Adv. 2014 4, 9092-9097.
Foley, T. L., Rai, G., Yasgar, A., Daniel, T., Baker, H. L., Attene-Ramos, M., Kosa, N. M., Leister, W., Burkart, M. D., Jadhav, A., Simeonov, A., & Maloney, D. J. 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide (ML267), a potent inhibitor of bacterial phosphopantetheinyl transferase that attenuates secondary metabolism and thwarts bacterial growth. J. Med. Chem. 2014 57(3), 1063-1078.
Kosa, N. M., Pham, K. M., & Burkart, M. D. Chemoenzymatic exchange of phosphopantetheine on protein and peptide. Chem. Sci. 2014 5, 1179-1186.
Beld, J., Sonnenschein, E. C., Vickery, C. R., Noel, J. P., & Burkart, M. D. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life. Nat. Prod. Rep. 2014 31, 61-108.
Kosa, N. M., Foley, T. L., & Burkart, M. D. Fluorescent techniques for discovery and characterization of phosphopantetheinyl transferase inhibitors. J. Antibiot. 2014 67, 113-120.
Nguyen, C., Haushalter, R. W., Lee, D. J., Markwick, P. R., Bruegger, J., Caldara-Festin, G., Finzel, K., Jackson, D. R., Ishikawa, F., O'Dowd, B., McCammon, J. A., Opella, S. J., Tsai, S. C. & Burkart, M. D. Trapping the dynamic acyl carrier protein in fatty acid biosynthesis. Nature 2014 505, 427-431.
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2013
Balaian, L., Crews, L. A., Zipeto, M., Anna, K., Ball, E. D., Burkart, M. D., & Jamieson, C. H. M. A highly selective SF3B1-targeted splicing inhibitor reduces human CD34+ cell survival and self-renewal in acute myeloid leukemia. Blood 2013 122, 1653.
Javidpour, P., Bruegger, J., Srithahan, S., Korman, T. P., Crump, M. P., Crosby, J., Burkart, M. D., & Tsai, S. C. The determinants of activity and specificity in Actinorhodin type II polyketide ketoreductase. Chem. Biol. 2013 20(10), 1225-1234.
Bruegger, J., Haushalter, B., Vagstad, A., Shakya, G., Mih, N., Townsend, C. A., Burkart, M. D., & Tsai, S. C. Probing the selectivity and protein⋅ protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers. Chem. Biol. 2013 20(9), 1135-1146.
Villa, R., Kashyap, M. K., Kumar, D., Kipps, T. J., Castro, J. E., La Clair, J. J., & Burkart, M. D. Stabilized cyclopropane analogs of the splicing inhibitor FD-895. J. Med. Chem. 2013 56(17), 6576-6582.
Thomsen, M., Vogensen, S. B., Buchardt, J., Burkart, M. D., & Clausen, R. P. Chemoenzymatic synthesis and in situ application of S-adenosyl-L-methionine analogs. Org. Biomol. Chem. 2013 11, 7606-7610.
Ishikawa, F., Haushalter, R. W., Lee, D. J., Finzel, K., & Burkart, M. D. Sulfonyl 3-alkynyl pantetheinamides as mechanism-based cross-linkers of acyl carrier protein dehydratase. J. Am. Chem. Soc. 2013 135(24), 8846-8849.
Stewart Jr., C., Vickery, C. R., Burkart, M. D., & Noel, J. P. Confluence of structural and chemical biology: plant polyketide synthases as biocatalysts for a bio-based future. Curr. Opin. Plant. Biol. 2013 16(3), 365-372.
Yu, W. L., Jones, B. D., Kang, M., Hammons, J. C., La Clair, J. J., & Burkart, M. D. Spirohexenolide A targets human macrophage migration inhibitory factor (hMIF). J. Nat. Prod. 2013 76(5), 817-823.
Burkart, M. D., & Mayfield, S. P. Biofuels for the 21st century. Curr. Opin. Chem. Biol. 2013 17(3), 436-438.
Blatti, J. L., Michaud, J., & Burkart, M. D. Engineering fatty acid biosynthesis in microalgae for sustainable biodiesel. Curr. Opin. Chem. Biol. 2013 17(3), 496-505.
Rothmann, M., Kang, M., Villa, R., Ntai, I., La Clair, J. J., Kelleher, N. L., Chapman, E. & Burkart, M. D. Metabolic perturbation of an essential pathway: Evaluation of a glycine precursor of coenzyme A. J. Am. Chem. Soc. 2013 135(16), 5962-5965.
Lipson, J. M., Thomsen, M., Moore, B. S., Clausen, R. P., La Clair, J. J., & Burkart, M. D. A tandem chemoenzymatic methylation by S-adenosyl-L-methionine. ChemBioChem 2013 14, 950-953.
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2012
Hur, G. H., Vickery, C. R., & Burkart, M. D. Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology. Nat. Prod. Rep. 2012 29, 1074-1098.
Villa, R., Mandel, A. L., Jones, B. D., La Clair, J. J., & Burkart, M. D. Structure of FD-895 revealed through total synthesis. Org. Lett. 2012 14(21), 5396-5399.
Kosa, N. M., Haushalter, R. W., Smith, A. R., & Burkart, M. D. Reversible labeling of native and fusion-protein motif. Nat. Methods 2012 9, 981-984.
Blatti, J. L., Beld, J., Behnke, C. A., Mendez, M., Mayfield, S. P., & Burkart, M. D. Manipulating fatty acid biosynthesis in microalgae for biofuel through protein-protein interactions. PLoS One 2012 7(9): e42949.
Van Der Westhuyzen, R.; Hammons, J. C.; Meier, J. L.; Dahesh, S., Moolman, W. J. A., Pelly, S. C., Nizet, V., Burkart, M. D., & Strauss, E. The antibiotic CJ-15,801 is an antimetabolite that hijacks and then inhibits CoA biosynthesis. Chem. Biol. 2012 19(5), 559-571.
Blatti, J. L., & Burkart, M. D. Releasing stored solar energy within pond scum: Biodiesel from algal lipids. J. Chem. Educ. 2012 89(2), 239-242.
Ishikawa, F., Haushalter, R. W., & Burkart, M. D. Dehydratase-specific probes for fatty acid and polyketide synthases. J. Am Chem. Soc. 2012 134(2), 769-772.
Rothmann, M., Niessen, S., Haushalter, R. W., Cravatt, B. F., & Burkart, M. D. Resin-based investigation of acyl carrier protein interaction networks in Escherichia coli. Bioorgan. Med. Chem. 2012 20(2), 667-671.
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2011
La Clair, J. J., Rheingold, A. L., & Burkart, M. D. Ganodone, a bioactive benzofuran from the fruiting bodies of Ganoderma tsugae. J. Nat. Prod. 2011 74(10), 2045-2051.
Jones, A. C., Monroe, E. A., Podell, S., Hess, W. R., Klages, S., Esquenazi, E., Niessen, S., Hoover, H., Rothmann, M., Lasken, R. S., Yates III, J. R., Reinhardt, R., Kube, M., Burkart, M. D., Allen, E. E., Dorrestein, P. C., Gerwick, W. H., & Gerwick, L. Genomic insights into the physiology and ecology of the marine filamentous cyanobacterium Lyngbya majuscula. Proc. Natl. Acad. Sci. U. S. A. 2011 108(21), 8815-8820.
Yu, W. L., Ansari, W., Schoepp, N. G., Hannon, M. J., Mayfield, S. P., & Burkart, M. D. Modifications of the metabolic pathways of lipid and triacylglycerol production in microalgae. Microb. Cell. Fact. 2011 10:91.
Haushalter, R. W., Filipp, F. V., Ko, K. S., Yu, R., Opella, S. J., & Burkart, M. D. Binding and pKa modulation of a polycyclic substrate analogue in a type II polyketide acyl carrier protein. ACS Chem. Biol. 2011 6(5), 413-418.
Worthington, A. S., Hur, G. H., & Burkart, M. D. Activity-guided engineering of natural product carrier proteins. Mol. BioSyst. 2011 7, 365-370.
Meier, J. L., & Burkart, M. D. Proteomic analysis of polyketide and nonribosomal peptide biosynthesis. Curr. Opin. Chem. Biol. 2011 15(1), 48-56.
Meier, J. L., Patel, A. D., Niessen, S., Meehan, M., Kersten, R., Yang, J. Y., Rothmann, M., Cravatt, B. F., Dorrestein, P. C., Burkart, M. D., & Bafna, V. Practical 4′-phosphopantetheine active site discovery from proteomic samples. J. Proteome. Res. 2011 10(1), 320-329.
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2010
Reyes, C. P., La Clair, J. J., & Burkart, M. D. Metabolic probes for imaging endosymbiotic bacteria within toxic dinoflagellates. Chem. Commun. 2010 46, 8151-8153.
Ko, K. S., Alexander, M. D., Fontaine, S. D., Biggs-Houck, J. E., La Clair, J. J., & Burkart, M. D. Synthetic studies on the mycolactone core. Org. Biomol. Chem. 2010 8, 5159-5165.
Yu, W. L., Guizzunti, G., Foley, T. L., Burkart, M. D., & La Clair, J. J. An optimized immunoaffinity fluorescent method for natural product target elucidation. J. Nat. Prod. 2010 73(10), 1659-1666.
Foley, T. L., Yasgar, A., Garcia, C. J., Jadhav, A., Simeonov, A., & Burkart, M. D. Preparation of FRET reporters to support chemical probe development. Org. Biomol. Chem. 2010 8, 4601-4606.
Jones, B. D., La Clair, J. J., Moore, C. E., Rheingold, A. L., & Burkart, M. D. Convergent route to the spirohexenolide macrocycle. Org. Lett. 2010 12(20), 4516-4519.
Meier, J. L., Haushalter, R. W., & Burkart, M.D. A mechanism based protein crosslinker for acyl carrier protein dehydratases. Bioorgan. Med. Chem. Lett. 2010 20(16), 4936-4939.
Worthington, A. S., Porter, D. F., & Burkart, M. D. Mechanism-based crosslinking as a gauge for functional interaction of modular synthases. Org. Biomol. Chem. 2010 8, 1769-1772.
Yasgar, A., Foley, T. L., Jadhav, A., Inglese, J., Burkart, M. D., & Simeonov, A. A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase. Mol. BioSyst. 2010 6, 365-375.
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2009
Kang, M., Jones, B. D., Mandel, A. L., Hammons, J. C., DiPasquale, A. G., Rheingold, A. L., La Clair, J. J., & Burkart, M. D. Isolation, structure elucidation, and antitumor activity of spirohexenolides A and B. J. Org. Chem. 2009 74(23), 9054-9061.
Lear, M. J., Simon, O., Foley, T. L., Burkart, M. D., Baiga, T. J., Noel, J. P., DiPasquale, A. G., Rheingold, A. L., & La Clair, J. J. Laetirobin from the parasitic growth of Laetiporus sulphureus on Robinia pseudoacacia. J. Nat. Prod. 2009 72(11), 1980-1987.
Meier, J. L., Niessen, S., Hoover, H. S., Foley, T. L., Cravatt, B. F., & Burkart, M. D. An Orthogonal Active Site Identification System (OASIS) for proteomic profiling of natural product biosynthesis. ACS Chem. Biol. 2009 4(11), 948-957.
Najmabadi, P., Lee, H. H., Aung, T., Thuya, A., Ng, J., La Clair, J. J., & Burkart, M. D. Grafta: A 3D environment for biomolecular networks. International Journal of Bioinformatics Research and Applications (IJBRA) 2009 5(5), 564-569.
Mercer, A. C., Meier, J. L., Torpey, J. W., & Burkart, M. D. In vivo modification of native carrier protein domains. ChemBioChem 2009 10, 1091-1100.
Meier, J. L., & Burkart, M. D. Synthetic probes for polyketide and nonribosomal peptide biosynthetic enzymes. Methods in Enzymology 2009 Chapter 9, Vol. 458, 219-254.
Meier, J. L., & Burkart, M. D. The chemical biology of modular biosynthetic enzymes. Chem. Soc. Rev. 2009 38, 2012-2045.
Hur, G. H., Meier, J. L., Baskin, J., Codelli, J. A., Bertozzi, C. R., Marahiel, M. A., & Burkart, M. D. Crosslinking studies of protein-protein interactions in nonribosomal peptide biosynthesis. Chem. Biol. 2009 16(4), 372-381.
Foley, T. L., Young, B. S., & Burkart, M. D. Phosphopantetheinyl transferase inhibition and secondary metabolism. FEBS Journal 2009 276, 7134-7145.
Foley, T. L., & Burkart, M. D. A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Anal. Biochem. 2009 394(1), 39-47.
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2008
Worthington, A. S., Hur, G. H., Meier, J. L., Cheng, Q., Moore, B. S., & Burkart, M. D. Probing the compatibility of type II ketosynthase-carrier protein partners. ChemBioChem 2008 9, 2096-2103.
Najmabadi, P., Ko, K. S., La Clair, J. J., & Burkart, M. D. A method for fabrication of polycarbonate-based bioactive platforms. Journal of the Association for Laboratory Automation 2008 13(5), 284-288.
Mercer, A. C., Meier, J. L., Hur, G. H., Smith, A. R., & Burkart, M. D. Antibiotic evaluation and in vivo analysis of alkynyl Coenzyme A antimetabolites in Escherichia coli. Bioorgan. Med. Chem. Lett. 2008 18(22), 5991-5994.
Meier, J. L., Mercer, A. C., & Burkart, M. D. Fluorescent profiling of modular biosynthetic enzymes by complementary metabolic and activity based probes. J. Am. Chem. Soc. 2008 130(16), 5443-5445.
Meier, J. L., Barrows-Yano, T., Foley, T. L., Wike, C. L., & Burkart, M. D. The unusual macrocycle forming thioesterase of mycolactone. Mol. BioSyst. 2008 4, 663-671.
Kapur, S., Worthington, A., Tang, Y., Cane, D. E., Burkart, M. D., & Khosla, C. Mechanism based protein crosslinking of domains from the 6-deoxyerythronolide B synthase. Bioorgan. Med. Chem. Lett. 2008 18(10), 3034-3038.
Haushalter, R. W., Worthington, A. S., Hur, G. H., & Burkart, M. D. An orthogonal purification strategy for isolating crosslinked domains of modular synthases. Bioorgan. Med. Chem. Lett. 2008 18(10), 3039-3042.
Ko, K. S., Najmabadi, P., La Clair, J. J., & Burkart, M. D. Affinity analyses on moldable optical polycarbonate. Chembiochem 2008 9, 201-205.
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2007
Mandel, A. L., Jones, B. D., La Clair, J. J., & Burkart, M. D. A synthetic entry to pladienolide B and FD-895. Bioorg. Med. Chem. Lett. 2007 17(18), 5159-5164.
Mercer, A. C., & Burkart, M. D. The ubiquitous carrier protein—a window to metabolite biosynthesis. Nat. Prod. Rep. 2007 24, 750-773.
Worthington, A. S., & Burkart, M. D. The old is new again: asparagine oxidation in calcium-dependent antibiotic biosynthesis. ACS Chem. Biol. 2007 2(3), 152-154.
Najmabadi, P., La Clair, J. J., & Burkart, M. D. A systems perspective to digital structures in molecular analysis. Org. Biomol. Chem. 2007 5, 214-222.
Foley, T. L., & Burkart, M. D. Site-specific protein modification: advances and applications. Curr. Opin. Chem. Biol. 2007 11(1), 12-19.
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2003 - 2006
Worthington, A. S., Rivera Jr., H., Torpey, J. W., Alexander, M. D., & Burkart, M. D. Mechanism-based protein cross-linking probes to investigate carrier protein-mediated biosynthesis. ACS Chem. Biol. 2006 1(11), 687-691.
Alexander, M. D., Fontaine S. D., La Clair, J. J., DiPasquale, A. G., Rheingold, A. L., & Burkart, M. D. Synthesis of the mycolactone core by ring-closing metathesis. Chem. Commun. 2006 0, 4602 - 4604.
Mercer, A. C., & Burkart, M. D. Chemical expansion of cofactor activity. Nat. Chem. Biol. 2006 2, 8-10.
La Clair, J. J., & Burkart, M. D. Geometry in digital molecular arrays. Org. Biomol. Chem. 2006 4, 3052-3055.
Meier, J. L., Mercer, A. C., Rivera Jr., H., & Burkart, M. D. Synthesis and evaluation of bioorthogonal pantetheine analogues for in vivo protein modification. J. Am. Chem. Soc. 2006 128(37), 12174-12184.
Worthington, A. S., & Burkart, M. D. One-pot chemo-enzymatic synthesis of reporter-modified proteins. Org. Biomol. Chem. 2006 4, 44-46.
Mercer, A. C., & Burkart, M. D. Enzyme-assisted antibiotic engineering- the wright way. Chem. Biol. 2005 12(2), 147-148.
Shute, T. S., Matsushita, M., Dickerson, T. J., La Clair, J. J., Janda, K. D., & Burkart, M. D. A site-specific bifunctional protein labeling system for affinity and fluorescent analysis. Bioconjugate Chem. 2005 16(6), 1352-1355.
Mercer, A. C., La Clair, J. J., & Burkart, M. D. Fluorescent multiplex analysis of carrier protein post-translational modification. ChemBioChem 2005 6, 1335-1337.
Clarke, K. M., La Clair, J. J., & Burkart, M. D. A three-component photoreversible tag for thiols. J. Org. Chem. 2005 70(9), 3709-3711.
Clarke, K. M., Mercer, A. C., La Clair, J. J., & Burkart, M. D. In vivo reporter labeling of proteins via metabolic delivery of Coenzyme A analogues. J. Am. Chem. Soc. 2005 127(32), 11234-11235.
Mandel, A. L., La Clair, J. J., & Burkart, M. D. Modular synthesis of pantetheine and phosphopantetheine. Org. Lett. 2004 6(26), 4801-4803.
La Clair, J. J., Foley, T. L., Schegg, T. R., Regan, C. M., & Burkart, M. D. Manipulation of carrier proteins in antibiotic biosynthesis. Chem. Biol. 2004 11(2), 195-201.
Burkart, M. D. Metabolic engineering-a genetic toolbox for small molecule organic synthesis. Org. Biomol. Chem. 2003 1, 1-4.
La Clair, J. J., & Burkart, M. D. Molecular screening on a compact disc. Org. Biomol. Chem. 2003 1, 3244-3249.
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